N-Succinimidyl 6-maleimidohexanoate

Name	N-succinimidyl 6-maleimidocaproate
Synonyms	Mal-heptanoic NHS ester N-succinimidyl 6-maleimidocaproate N-Succinimidyl 6-maleimidohexanoate N-(6-MALEIMIDOCAPROYLOXY)SUCCINIMIDE N-(E-MALEIMIDOCAPROYLOXY)SUCCINIMIDE EMCS N-Succinimidyl 6-maleimidohexanoate N-(EPSILON-MALEIMIDOCAPROYLOXY)SUCCINIMIDE N-(epsilon-Maleimidocaproyloxy)succinimide N-[EPSILON-MALEIMIDOCAPROYLOXY]SUCCINIMIDE ESTER 6-Maleimidohexanoic acid N-hydroxysuccinimide ester (2,5-Dioxopyrrolidin-1-yl) 6-(2,5-dioxopyrrol-1-yl)hexanoate 1-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-1H-pyrrole-2,5-dione
CAS	55750-63-5
EINECS	637-238-5
InChI	InChI=1/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2

Molecular Formula	C14H16N2O6
Molar Mass	308.29
Density	1.40±0.1 g/cm3(Predicted)
Melting Point	70-73°C(lit.)
Boling Point	480.6±47.0 °C(Predicted)
Flash Point	244.5°C
Solubility	chloroform: 100mg/mL
Vapor Presure	2.13E-09mmHg at 25°C
Appearance	powder
Color	Off-white to pale brown
BRN	1499815
pKa	-2.21±0.20(Predicted)
Storage Condition	-20°C
Sensitive	Light & Moisture Sensitive & Hygroscopic
Refractive Index	1.577
MDL	MFCD00043043
Use	A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity
In vitro study	6-Maleimidohexanoic acid N-hydroxysuccinimide ester is coupled to the peptides, and then conjugated to the Adenovirus vector containing luciferase gene as adenovirus vector carrier.

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	8-10-21
HS Code	29280000

Introduction	succinimidyl 6-(maleimidyl) hexanoate is a heterobifunctional crosslinking reagent, prolonged interval binding to amine and thiol reactivity. Typically, the initial coupling to the molecule containing the primary amine is through an amide bond buffered at pH 7.5 (6.5-8.5), the second coupling is through a pH 6.8 buffered thioether linkage to a molecule containing a free thiol group (6.5-7.0).
Application	6-(maleimidyl) hexanoic acid succinimide ester can be used for the preparation of enzyme immune coupling agent and hapten carrier molecular coupling agent. Contains a linker of 9 atoms. The extended fatty spacer stabilizes the maleimide prior to coupling compared to the aromatic spacer.
biological activity	6-maleimidoexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linker. EMCS is a unique and useful reagent for the preparation of hapten conjugates and enzyme immunoconjugates.

Last Update：2024-04-09 02:00:09

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N-Succinimidyl 6-maleimidohexanoate

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